Publications
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Shared and unique brain network features predict cognition, personality and mental health in childhood
Publications ·The manner through which individual differences in brain network organization track population-level behavioral variability is a fundamental question in systems neuroscience. Recent work suggests that resting-state and task-state functional connectivity can predict specific traits at the individual level. However, the focus of most studies on single behavioral traits has come at the expense of capturing broader relationships across behaviors. Here,...
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A highly predictive signature of cognition and brain atrophy for progression to Alzheimer's dementia
Publications ·Clinical trials in Alzheimer’s disease need to enroll patients whose cognition will decline over time, if left untreated, in order to demonstrate the efficacy of an intervention. Machine learning models used to screen for patients at risk of progression to dementia should therefore favor specificity (detecting only progressors) over sensitivity (detecting all progressors), especially when the prevalence of progressors is...
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A dataset of multiresolution functional brain parcellations in an elderly population with no or mild cognitive impairment
Publications ·We present eight resolutions of brain parcellations for clusters generated at the group level from resting-state functional magnetic resonance images for 99 cognitively normal elderly persons and 129 patients with mild cognitive impairment, pooled from four independent datasets. This dataset was generated as part of the following study: Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four...
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Common effects of amnestic mild cognitive impairment on resting-state connectivity across four independent studies
Publications ·Resting-state functional connectivity is a promising biomarker for Alzheimer’s disease. However, previous resting-state functional magnetic resonance imaging studies in Alzheimer’s disease and amnestic mild cognitive impairment (aMCI) have shown limited reproducibility as they have had small sample sizes and substantial variation in study protocol. We sought to identify functional brain networks and connections that could consistently discriminate normal aging from...
Software
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SPM12 tools for Octave
Software ·Have you ever wanted to run some tissue segmentations or spatial normalization on brain images with SPM12, but you didn’t have a MATLAB license? Or did you ever wish that these SPM12 tools could be run in an open source language, perhaps Octave?
Miscellaneous
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3D printed brain
Miscellaneous ·Here’s a brief summary of how I built the 3D printed brain lamp that is frequently featured as my website’s banner. I want to acknowledge my friends Sebastian Urchs, for advising me on how to build and get my prints started, and Yassine Benhajali, for teaching me and helping me build the circuit.